Roger (Jeff Daniels) and Anita (Joely Richardson) meet and fall in love whilst out walking their dogs, Pongo and Perdy. They are married, and their hounds also prove compatible, producing a litter of fifteen black and white puppies. However, Anita's boss, fashion designer Cruella DeVil (Glenn Close), wants to skin the pups and turn them into a coat. To this end she sends her henchmen Jasper (Hugh Laurie) and Horace (Mark Williams) to kidnap the tiny canines.