Romantic comedy starring Jake Gyllenhaal and Anne Hathaway, based on the non-fiction book 'Hard Sell: The Evolution of a Viagra Salesman' by Jamie Reidy. Jamie (Gyllenhaal) is an ambitious and promiscuous pharmaceutical salesman who has always kept his emotions firmly in check as he uses his infallible charm to get his way in his job and in his encounters with women. But when he meets free-spirited artist Maggie (Hathaway), he is perplexed to find that his usual box of tricks has little effect. Before long he has become hopelessly infatuated with her, but there is a reason why she won't let him get close, as Jamie is about to discover.