Sperm Nuclear Maturation : A Basic & Clinical Approach Paperback / softback
In somatic cells, DNA is normally wrapped around the histones octamer to forms nucleosomes that eventually give rise to a solenoid DNA structure.
Unlike somatic cells, in mammalian sperm, the development of spermatids into mature spermatozoa is accomplished by a series of structural and chemical modifications including a gradual replacement of lysine-rich histones by transition proteins and then by protamines which bind more tightly to DNA than histones, which results in compaction of chromatin in the sperm nucleus, a process which is termed 'sperm chromatin condensation'.
This book examines the several techniques that have been devised in order to study chromatin and DNA defects in human spermatozoa.
- Format: Paperback / softback
- Pages: 129 pages
- Publisher: Nova Science Publishers Inc
- Publication Date: 21/10/2011
- Category: DNA & Genome
- ISBN: 9781616681944