Eicosanoids, Inflammation & Chronic Inflammatory Diseases : Pathophysiology, Health Effects & Targets for Therapies, Hardback Book

Eicosanoids, Inflammation & Chronic Inflammatory Diseases : Pathophysiology, Health Effects & Targets for Therapies Hardback

Edited by Carmela Rita Balistreri

Description

Eicosanoids constitute a large and expanding family of bioactive lipids synthesized from polyunsaturated fatty acids (PUFA) to either pro-inflammatory omega-6 arachidonic acid (AA) or anti-inflammatory omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

In these last cases, two essential fatty acids (FAs) ( -6 linoleic acid (C18:2n6) and -3 linolenic acid (LA) (C18:3n3) are utilized as substrates and a series of desaturase and elongase enzymes are essential for their production.

Among these different members, the AA-derived eicosanoids operate as potent signaling mediators that provide an efficient way for cells to respond to various stimuli.

As a result, they act as part of a complex regulatory network and control a number of important physiological processes.

Some of these processes include: smooth muscle tone; vascular permeability; platelet aggregation; broncho-constriction/dilation; intestine motility.

Information

  • Format: Hardback
  • Pages: 272 pages
  • Publisher: Nova Science Publishers Inc
  • Publication Date:
  • Category: Physiology
  • ISBN: 9781634827997

£180.00

£143.95

 
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