Structural Biology in Drug Discovery : Methods, Techniques, and Practices, Hardback Book

Structural Biology in Drug Discovery : Methods, Techniques, and Practices Hardback


With the most comprehensive and up-to-date overview of structure-based drug discovery and using experimental and computational approaches, this book covers principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development.

Presents the benefits, limitations, and potentiality of novel techniques in the field, like complex crystallization, X-ray diffraction, NMR, mass spectrometry, and computational chemistry Assesses macromolecular structures with experimental, analytical, and therapeutic approaches to reveal a successful, multidisciplinary perspective to drug development Includes detailed chapters on concepts, like protein dynamics, structure-based chemogenomics and polypharmacology, and fragment-based drug design Illustrates advances in biomolecular targeting using case studies and emerging examples: epigenetic proteins, HCV inhibitors, HIV-1 inhibitors, ribosomes, and antibodies


  • Format: Hardback
  • Pages: 448 pages
  • Publisher: John Wiley & Sons Inc
  • Publication Date:
  • Category: Chemistry
  • ISBN: 9781118681015



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