Supporting your high street Find out how »
Basket Image


The Actin Cytoskeleton in Cell Motility, Cancer, and Infection, PDF eBook

The Actin Cytoskeleton in Cell Motility, Cancer, and Infection PDF

Part of the Colloquium Series on The Cell Biology of Medicine series

Please note: eBooks can only be purchased with a UK issued credit card and all our eBooks (ePub and PDF) are DRM protected.


By now it is abundantly clear that the cells of our bodies have the ability to move because of their actin cytoskeleton.

From the earliest cell migrations in the embryo that serve to form the primordial tissue layers to the outgrowth of neurons, the contractions of our heart and skeletal muscles, and the metastasis of cancer cells, it is the regulated action of the actin cytoskeleton that propels our various motions.

In this chapter we will examine the biochemical and cell biological mechanisms that control actin-based cell motility.

We will see that cell migration along a substratum occurs in three fundamental phases that are exquisitely orchestrated in sequence.

Cell migration occurs by an initial extension of the front edge of the cell, followed closely by contraction of the cell's rear end to push cytoplasm into the newly formed extension.

As the cell's new leading edge extends, attachment sites are assembled on the cell floor, and extend through the plasma membrane to couple the migrating cell to the underlying surface.

How the cell knows where to go, when to detach and reattach during the migration, and how to keep each process under strict control is a story well worth hearing, because it is motility and adhesion that make a multicellular life such as ours possible. Table of Contents: The Cytoskeleton / How Cells Move / Regulation of the Actin Cytoskeleton / The Role of Myosin in Cell Motility / The Role of Cell Adhesion in Cell Motility / Recommended Readings


  • Format: PDF
  • Pages: 57 pages
  • Publisher: Biota Publishing
  • Publication Date:
  • Category: Molecular biology
  • ISBN: 9781615040070

Other Formats



Available to Download
Delivered to your inbox

to transfer to your device

Also in the Colloquium Series on The Cell Biology of Medicine series   |  View all