Vaccine Efficacy Evaluation : The Gnotobiotic Pig Model Paperback / softback
by Lijuan (Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, Virgini Yuan
Part of the Pocket Guides to Biomedical Sciences series
Paperback / softback
Description
Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development.
Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines.
The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines.
Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines.
This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection. Key Features Provides a natural history of human rotavirus and norovirus infection in Gn pigs Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluationEvaluates various candidate rotavirus and norovirus vaccinesDiscusses human gut microbiota transplanted Gn pig modelsDocuments the role of probiotics and rice bran as prophylactics and vaccine adjuvants
Information
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Less than 10 available - usually despatched within 24 hours
- Format:Paperback / softback
- Pages:189 pages, 30 Tables, black and white; 10 Line drawings, color; 58 Line drawings, black and white; 1
- Publisher:Taylor & Francis Ltd
- Publication Date:13/04/2022
- Category:
- ISBN:9780367486341
Information
-
Less than 10 available - usually despatched within 24 hours
- Format:Paperback / softback
- Pages:189 pages, 30 Tables, black and white; 10 Line drawings, color; 58 Line drawings, black and white; 1
- Publisher:Taylor & Francis Ltd
- Publication Date:13/04/2022
- Category:
- ISBN:9780367486341
