Environmental Epigenomics in Health and Disease : Epigenetics and Disease Origins, Hardback Book

Environmental Epigenomics in Health and Disease : Epigenetics and Disease Origins Hardback

Edited by Randy L. Jirtle, Frederick L. Tyson

Part of the Epigenetics and Human Health series


There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors.

Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA.

The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs.

The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis.

Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species.

The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.


  • Format: Hardback
  • Pages: 302 pages, 1 Tables, color; 3 Tables, black and white; XV, 302 p.
  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Publication Date:
  • Category: Environmental factors
  • ISBN: 9783642233791



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