Type I Interferon in Autoimmune Diseases & Its Clinical Applications Hardback
Edited by Yihong Yao
Auto-immune diseases such as systemic lupus erythematosus (SLE), Sjoegren's syndrome, psoriasis, scleroderma (SSc) and myositis are heterogeneous disorders that result from interactions between genetic and environmental factors.
Type I interferons (IFNs), especially IFN- /ss, have multiple biological functions including anti-viral and anti-bacterial properties, immuno-modulation, anti-proliferation, and intensive studies over decades have also revealed important roles in auto-immunity and cancer.
Sustained Type I IFN elevation has been implicated in immune responses against self-antigens and tissue damage, which has led to the hypothesis that type I IFN might play a critical role in the pathogenesis of some auto-immune and inflammatory diseases.
This book provides an overview of many key topics surrounding type I IFNs, beginning with detailed discussion of the type I IFN signalling pathway, the interplay between components that regulate this pathway, its involvement in auto-immunity, and a detailed review of the roles of type I IFNs in a series of well characterised inflammatory and auto-immune diseases.
- Format: Hardback
- Pages: 349 pages
- Publisher: Nova Science Publishers Inc
- Publication Date: 19/06/2013
- Category: Immunology
- ISBN: 9781624173790