Redox-Active Therapeutics PDF

Edited by Ines Batinic-Haberle, Julio S. Reboucas, Ivan Spasojevic

Part of the Oxidative Stress in Applied Basic Research and Clinical Practice series

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Description

This essentialvolume comprehensively discusses redox-active therapeutics, focusingparticularly on their molecular design, mechanistic, pharmacological andmedicinal aspects. The first section of the book describes the basicaspects of the chemistry and biology of redox-active drugs and includes a briefoverview of the redox-based pathways involved in cancer and the medical aspectsof redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerativediseases, pain, radiation injury and radioprotection (such as of brain, lungs, headand neck and erectile function) and neglected diseases (e.g., leishmaniasis). It encompasses several major classes of redox-active experimental therapeutics, whichinclude porphyrins, salens, nitrones, and most notably metal-containing (e.g.,Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations withnanomaterials and quantum dots. Numerous illustrations, tablesand figures enhance and complement the text; extensive references to relevantliterature are also included.

Redox-Active Therapeutics is an invaluable addition to Springer’s OxidativeStress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate studentsinterested in understanding and exploring the Redoxome—the organism redoxnetwork—as an emerging frontier in drug design, redox biology and medicine.