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The Serotonin Receptors : From Molecular Pharmacology to Human Therapeutics, Hardback Book

The Serotonin Receptors : From Molecular Pharmacology to Human Therapeutics Hardback

Edited by Bryan L. Roth

Part of the The Receptors series

Hardback

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A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery.

The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted.

They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice.

Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

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