Description
Serotonin (5-HT) was isolated and chemically characterized nearly four decades ago, and is now generally accepted to function as a neurotransmitter and neuromodulatory agent.
Early research focused on the measurement of concentrations, synthesis, and metabolism of 5-HT, and only recently has the focus shifted to characterization of 5-HT receptors.
Gaddum and Picarelli first sug- gested in 1957 that the effect of 5-HT in the guinea pig ileum is mediated by two pharmacologically distinguishable receptors; however, the possibility of dual5-HT receptors was not explored systematically or successfully until the past decade.
It is now clear that more, perhaps many more, subclasses of 5-HT receptors exist.
The purpose of this book is to provide an up-to-date report on 5-HT receptors.
This is a difficult task considering the astonishing speed at which research in this field is expanding.
As the first of what we can expect to be a steady stream of monographs focusing on 5-HT receptors, the book confirms that we are in an exciting time in the history of 5-HT.
For those of us who have been work- ing on 5-HT for many years, our dream of equal progress and recognition with the more extensively studied catecholamines is finally being realized.
We now have a Serotonin Club that held its first international scientific meeting in 1987, and several more international meetings are in the planning stages.
Information
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Download - Immediately Available
- Format:PDF
- Publisher:Humana Press
- Publication Date:06/12/2012
- Category:
- ISBN:9781461245605
Other Formats
- Hardback from £104.05
- Paperback / softback from £95.55
Information
-
Download - Immediately Available
- Format:PDF
- Publisher:Humana Press
- Publication Date:06/12/2012
- Category:
- ISBN:9781461245605
