Regulatory Genomics : RECOMB 2004 International Workshop, RRG 2004, San Diego, CA, USA, March 26-27, 2004, Revised Selected Papers Paperback / softback
Edited by Eleazar Eskin, Chris Workman
Part of the Lecture Notes in Bioinformatics series
Paperback / softback
Description
Research in the ?eld of gene regulation is evolving rapidly in an ever-changing s- enti?c environment.
Microarray techniques and comparative genomics have enabled more comprehensive studies of regulatory genomics and are proving to be powerful tools of discovery.
The application of chromatin immunoprecipitation and microarrays (chIP-on-chip) to directly study the genomic binding locations of transcription factors has enabled more comprehensive modeling of regulatory networks.
In addition, c- plete genome sequences and the comparison of numerous related species has dem- strated that conservation in non-coding DNA sequences often provides evidence for cis-regulatory binding sites.
That said, much is still to be learned about the regulatory networks of these sequenced genomes.
Systematic methods to decipher the regulatory mechanism are also crucial for c- roboratingthese regulatorynetworks.Thecoreof thesemethodsarethe motifdiscovery algorithms that can help predict cis-regulatory elements.
These DNA-motif discovery programsarebecomingmoresophisticatedandare beginningto leverageevidencefrom comparative genomics (phylogenetic footprinting) and chIP-on-chip studies. How to use these new sources of evidence is an active area of research.
Information
-
Item not Available
- Format:Paperback / softback
- Pages:116 pages, VIII, 116 p.
- Publisher:Springer-Verlag Berlin and Heidelberg GmbH & Co. K
- Publication Date:16/02/2005
- Category:
- ISBN:9783540244561
Information
-
Item not Available
- Format:Paperback / softback
- Pages:116 pages, VIII, 116 p.
- Publisher:Springer-Verlag Berlin and Heidelberg GmbH & Co. K
- Publication Date:16/02/2005
- Category:
- ISBN:9783540244561
