Optimization in Drug Discovery : In Vitro Methods Hardback
Edited by Gary W. Caldwell, Zhengyin Yan
Part of the Methods in Pharmacology and Toxicology series
Hardback
Description
Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays.
Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.
Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.
Information
-
Item not Available
- Format:Hardback
- Pages:597 pages, 104 Tables, black and white; 49 Illustrations, color; 64 Illustrations, black and white;
- Publisher:Humana Press Inc.
- Publication Date:09/11/2013
- Category:
- ISBN:9781627037419
Information
-
Item not Available
- Format:Hardback
- Pages:597 pages, 104 Tables, black and white; 49 Illustrations, color; 64 Illustrations, black and white;
- Publisher:Humana Press Inc.
- Publication Date:09/11/2013
- Category:
- ISBN:9781627037419
