Catalytically Active Nucleic Acids Hardback
Edited by Harald Seitz, Frank Stahl, Johanna-Gabriela Walter
Part of the Advances in Biochemical Engineering/Biotechnology series
Hardback
Description
This volume reviews numerous reaction mechanisms and applications of nucleic acids with catalytic activity.
Written by an interdisciplinary team of authors, it provides an essential overview of these acids’ fundamental aspects, while also addressing associated methodologies such as nucleic acid enzyme engineering, peroxidase-mimicking DNAzymes and Aptazymes. After the discovery of natural ribozymes – RNA molecules that mediate the cleavage and formation of phosphodiester bonds and the formation of peptide bonds – numerous artificial ribozymes with altered catalytic activities were produced by in vitro and in vivo selection.
Unlike ribozymes, DNAzymes do not occur in nature. Although the catalytic activity of nucleic acid enzymes is usually much slower than that of proteins, nucleic acid enzymes with comparable catalytic activity have been obtained using stringent selection processes.
The key advantages of these enzymes: they are e.g. smaller, easier to produce and purify than proteins, and can withstand denaturation, e.g. by heat. Over the last few years, the number of publications on the applications of enzymatic nucleic acids has grown steadily.
Summarizing the fundamentals and applications of these acids, this book will not only be an excellent resource for experts in the field but will also guide young researchers just starting out in this significant area.
Information
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Out of stock
- Format:Hardback
- Pages:123 pages, 12 Illustrations, color; 26 Illustrations, black and white; VII, 123 p. 38 illus., 12 ill
- Publisher:Springer Nature Switzerland AG
- Publication Date:11/10/2019
- Category:
- ISBN:9783030296452
Information
-
Out of stock
- Format:Hardback
- Pages:123 pages, 12 Illustrations, color; 26 Illustrations, black and white; VII, 123 p. 38 illus., 12 ill
- Publisher:Springer Nature Switzerland AG
- Publication Date:11/10/2019
- Category:
- ISBN:9783030296452
