Caveolins and Caveolae : Roles in Signaling and Disease Mechanisms PDF
Edited by Jean-Francois Jasmin, Philippe Frank, Michael P. Lisanti
Part of the Advances in Experimental Medicine and Biology series
Description
Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids.
Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae.
The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3.
Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts.
On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles.
Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.
Information
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Download - Immediately Available
- Format:PDF
- Publisher:Springer New York
- Publication Date:12/03/2012
- Category:
- ISBN:9781461412229
Information
-
Download - Immediately Available
- Format:PDF
- Publisher:Springer New York
- Publication Date:12/03/2012
- Category:
- ISBN:9781461412229
