Gene Therapy for Cancer Hardback
Edited by Kelly K. Hunt, Stephan A. Vorburger, Stephen G. Swisher
Part of the Cancer Drug Discovery and Development series
Hardback
Description
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer.
Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles.
These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies.
Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches.
Thus far, almost two-thirds of gene therapy trials have focused on cancer.
This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Unlike the treatment of genetic defects, where expr- sion of the corrected gene needs to be strong, permanent and, sometimes regulated, tactics to treat tumors can be based on temporary and locally limited effects.
In addition, cancer cells have different properties than normal cells and this allows for targeting gene therapy to specific cells, a major advantage over current antitumor therapies, which are also toxic to normal cells and tissues.
Information
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Item not Available
- Format:Hardback
- Pages:469 pages, 26 Tables, black and white; 16 Illustrations, color; 69 Illustrations, black and white; X
- Publisher:Humana Press Inc.
- Publication Date:02/02/2007
- Category:
- ISBN:9781588294722
Information
-
Item not Available
- Format:Hardback
- Pages:469 pages, 26 Tables, black and white; 16 Illustrations, color; 69 Illustrations, black and white; X
- Publisher:Humana Press Inc.
- Publication Date:02/02/2007
- Category:
- ISBN:9781588294722
