Activities of Naringin-co (II) Metal Complexes : Anti-nociceptive Paperback / softback
by Rudra Narayan Sahoo, Lipsa Samal, Sudhanshu Sekhar Rout
Paperback / softback
Description
The activities of flavonoid are believed to increase when they are coordinated with transition metal ions.
An attempt was made to understand the contribution of the metal coordination & type of interaction between a flavonoid & metal ion & evaluation of its biological activity.
In this study a new metal complex of Co(II) with naringin was synthesized & characterized by FT-IR, UV-VIS spectrophotometer.
Groups of six mice were treated with Cobalt Naringin Complex (10 mg/kg body weight), administered IP.
Different tests were used for evaluating the anti-nociceptive effect or the influence on behavior of the tested substances on thermal nociception, chemical nociception & spontaneous behavior.
In the current study it has been evaluated that the complex has a Co(II) ion coordinated via 4 and 5 position of the flavonoid.
The metal binds with the flavonoid in the ratio 1:2, which was confirmed by Jobs method.
Our preliminary data for response latencies for hot-plate and tail- flick tests suggest that systemically administered CNC produces a significant analgesic effect under thermal thermal nociceptive stimulation.
The spontaneous behavior assay shows a significant decrease of activity.
Information
-
Out of stock
- Format:Paperback / softback
- Pages:56 pages
- Publisher:LAP Lambert Academic Publishing
- Publication Date:04/01/2021
- Category:
- ISBN:9786203201345
Information
-
Out of stock
- Format:Paperback / softback
- Pages:56 pages
- Publisher:LAP Lambert Academic Publishing
- Publication Date:04/01/2021
- Category:
- ISBN:9786203201345
