Regulation of Membrane Na+-K+ ATPase Paperback / softback
Edited by Sajal Chakraborti, Naranjan S Dhalla
Part of the Advances in Biochemistry in Health and Disease series
Paperback / softback
Description
Na+-K+ ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s a- and ß- subunits.
At present four different a- (a-1,a-2,a-3 and a-4) and three ß- (ß-1, ß-2, and ß-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific.
Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms.
Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties.
On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of a- and ß- subunits leading to an increased expression in the level of Na+-pump.
Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme.
These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembrane domain adjacent to the isoform(s) of a-ß subunits of Na+-K+ ATPase.
Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled “Regulation of Membrane Na+-K+ ATPase” for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.
Information
-
Available to Order - This title is available to order, with delivery expected within 2 weeks
- Format:Paperback / softback
- Pages:436 pages, 44 Illustrations, color; 56 Illustrations, black and white; XI, 436 p. 100 illus., 44 ill
- Publisher:Springer International Publishing AG
- Publication Date:27/03/2019
- Category:
- ISBN:9783319796727
Information
-
Available to Order - This title is available to order, with delivery expected within 2 weeks
- Format:Paperback / softback
- Pages:436 pages, 44 Illustrations, color; 56 Illustrations, black and white; XI, 436 p. 100 illus., 44 ill
- Publisher:Springer International Publishing AG
- Publication Date:27/03/2019
- Category:
- ISBN:9783319796727
