Comedy directed and co-written by Ben Stiller who also stars, reprising his role as dim but affable model Derek Zoolander.
When pop stars start being taken out by hitmen, giving the Zoolander signature 'Blue Steel' look before dying, FBI agent Melanie Valentina (Penélope Cruz) begins investigating.
She calls on Zoolander and Hansel (Owen Wilson) to infiltrate the new world of high fashion to uncover the truth about the pop star killings.
At this point, however, Zoolander and Hansel are now aged, washed-up models.
A complication arises in the form of their old foe Mugatu (Will Ferrell), who has been recently released from prison and is bent on revenge.
The all-star cast also features cameos from Ariana Grande, Justin Bieber, Kim Kardashian, Kanye West and Usher.