Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of a-Aryl Ketones PDF
by Robert Doran
Part of the Springer Theses series
Description
This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis.
Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity.
Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished.
During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.
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Download - Immediately Available
- Format:PDF
- Publisher:Springer International Publishing
- Publication Date:24/06/2015
- Category:
- ISBN:9783319205441
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Information
-
Download - Immediately Available
- Format:PDF
- Publisher:Springer International Publishing
- Publication Date:24/06/2015
- Category:
- ISBN:9783319205441
